Manchester United are set to face off against club legend Wayne Rooney after his Derby side beat Northampton in their replay.
Holders Manchester City have been paired with Sheffield Wednesday while Newcastle left it late to beat Oxford in their replay and now face a trip to Championship leaders West Brom.
All ties in the FA Cup fifth round are set to be played from March 3-5.
Full FA Cup fifth round draw:
• Sheffield Wednesday vs Manchester City
• Reading vs Sheffield United
• Chelsea vs Liverpool
• West Brom vs Newcastle
• Derby vs Manchester United
• Southampton/Tottenham vs Norwich
• Portsmouth vs Arsenal