Five time US Open Champion Roger Federer has been knocked out in Round of 16 encounter with world number 55, John Millman.

Unseeded Millman came from a set down to upset Federer beating him 3-6 7-5 7-6 7-6. He is the first tennis player ranked outside top 50 to beat Federer at Flushing Meadows.

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In other results:

K. Nishikori beat P. Kohlshcrieber 6-3 6-2 7-5

N. Djokovic beat J. Sousa 6-3 6-4 6-3

J. Del Potro beat B. Coric 6-4 6-3 6-1

Womens Singles:

N. Osaka beat A. Sabalenka 6-3 2-6 6-4

M. Keys beat D. Cibulkova 6-1 6-3

S. Stephens beat E. Mertens 6-3 6-3