Eddie Jones will look to maintain his perfect record as England head coach and simultaneously end a winless run against South Africa stretching back a decade.
The Red Rose followed a Six Nations grand slam with an historic 3-0 series victory over the Wallabies Down Under and can become the first team in 24 years to go unbeaten in a calendar year with a similar whitewash of the Springboks this autumn.
But England must end a sequence which has seen South Africa win 11 matches and draw one of 12 between the sides since England’s 23-21 win at Twickenham in 2006.
Two of those triumphs for the Boks came at the 2007 World Cup, where England were comprehensively beaten in the pool stages before narrowly missing out in a tight final.
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England have not gone so close to a second World Cup triumph since, but Mike Brown has set his sights on such a feat under Jones.
He said: “It’s great if, externally, we build something and people realise we are here but in the squad it just builds confidence and keeps pushing us forward towards the ultimate prize, which is being No1 in the world and winning World Cups.”
But the immediate challenge is Allister Coetzee’s South Africa. Below, Standard Sport brings you everything you need to know ahead of the first autumn international.
DATE, TIME AND VENUE
England face South Africa on Saturday November 12 at Twickenham Stadium, London. The game kicks off at 16:30 CAT.