Valencia became the first side to score five goals in the first half of a Europa League match as they thrashed Rapid Vienna 6-0 on manager Gary Neville’s 41st birthday.
Five days after Valencia won a league match under him for the first time, Neville saw his players race into a five-goal lead inside 35 minutes.
Santi Mina scored twice and set up three more in a sparkling performance.
The visitors improved after the break but Rodrigo wrapped up the win.
Santi Mina, 20, scored twice and assisted three more goals as Valencia tore Rapid Vienna apart.
The result matched Steaua Bucharest’s competition record.
With a Champions League place at stake for the winners of the Europa League, Neville could end the season on a high despite his side being 12th in La Liga.
Earlier on Thursday, holders Sevilla beat Molde 3-0 to take control of their last-32 tie.
Former Juventus striker Fernando Llorente struck twice and Kevin Gameiro added a third as Ole Gunnar Solskjaer’s men were well beaten.
Villarreal will also defend a lead next week after beating Napoli 1-0 thanks to a superb free-kick from Denis Suarez, while Borussia Dortmund took a large step towards qualification with a 2-0 home win over Porto.