England fly-half George Ford will be dropped for the World Cup Pool A match against Wales on Saturday, with Owen Farrell replacing him.
With injured centre Jonathan Joseph missing the game at Twickenham, rugby league convert Sam Burgess is set to start alongside Brad Barritt.
Burgess, 26, will be winning only his third England cap.
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Bath team-mate Joseph, 24, injured his chest as the hosts beat Fiji 35-11 in their opening match on Friday.
England attack coach Andy Farrell said Joseph’s injury was “nothing too serious” and would probably keep him out for “not more than a week”.
Joseph scored four tries in England’s Six Nations campaign earlier this year and is one of the most dangerous runners in England’s backline.
After facing Wales, England play Australia on 3 October and Uruguay on 10 October, with the top two teams from the group progressing to the quarter-finals.